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J Adv Periodontol Implant Dent. 2024;16(2): 94-102. doi: 10.34172/japid.2024.021
PMID: 39758269        PMCID: PMC11699261

Research Article

Efficacy of injectable platelet-rich fibrin (i-PRF) as a novel vehicle for local drug delivery in non-surgical periodontal pocket therapy: A randomized controlled clinical trial

Murugan Thamaraiselvan 1 * ORCID, Nadathur Doraisamy Jayakumar 1

Cited by CrossRef: 0

1- Costa F, de Souza S, Martins R, Costa B, Pires L, de Macedo A, Santos N, Huber S, Santos G, Kruel A, Santos M, Lana J. The Role of Injectable Platelet-Rich Fibrin in Orthopedics: Where Do We Stand?. CIMB. 2025;47(4):239 [Crossref]
2- Gawlak-Socka S, Jeżewska K, Bielecka-Kowalska N, Kłosek S. Adjunctive Use of Platelet-Derived Concentrates (Platelet-Rich Plasma, Platelet-Rich Fibrin, Concentrated Growth Factor, Platelet-Poor Plasma) in Non-Surgical Periodontal Therapy: Current Evidence and Comparative Analysis. JCM. 2026;15(2):554 [Crossref]
3- Niemczyk W, Kępa M, Żurek J, Aboud A, Skaba D, Wiench R. Comparative Evaluation of Platelet-Rich Fibrin (PRF) and Concentrated Growth Factor (CGF) as Carriers for Antibiotics—In Vitro Study. IJMS. 2025;26(9):4303 [Crossref]
4- Ozcan M, Topcu B, Alkaya B, Yılmaz M, Türer O, Haytac M. Effects of ascorbic acid and cholecalciferol on growth factor release, cytokines, and biomechanical properties of platelet rich fibrin: in vitro study. BMC Oral Health. 2026;26(1) [Crossref]
5- Kothekar M, Bajaj P, Dare S, Thakre S. Evaluation of the Effectiveness of Injectable Platelet-Rich Fibrin as an Adjuvant to One-Stage Full-Mouth Disinfection in Patients with Stage II and III Periodontitis: Protocol for a Randomized Clinical Trial. JMIR Res Protoc. 2026;15:e81032 [Crossref]
6- Han L, Wu X, Ouyang Q, Hu J, Sun S, Li X, Wang Z. The study on the construction of injectable tissue-engineered bone based on the injectable PRF combined with osteoblastic bone marrow mesenchymal stem cell sheets. Advances in Oral and Maxillofacial Surgery. 2025;19:100559 [Crossref]
7- Niemczyk W, Kępa M, Żurek J, Aboud A, Skaba D, Wiench R. Application of Platelet-Rich Fibrin and Concentrated Growth Factors as Carriers for Antifungal Drugs—In Vitro Study. JCM. 2025;14(14):5111 [Crossref]