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J Adv Periodontol Implant Dent. 2023;15(1): 22-27. doi: 10.34172/japid.2023.002
PMID: 37645550        PMCID: PMC10460776

Research Article

Effectiveness of Bromelain in the control of postoperative pain after periodontal surgery: A crossover randomized clinical trial

Masoumeh Faramarzi 1 * ORCID, Mehrnoosh Sadighi 1, Adileh Shirmohammadi 1, Reza Kazemi 2, Mahsa Zohdi 3 ORCID

Cited by CrossRef: 3

1- Dernovaya M, Nemeryuk D, Atrushkevich V. Oral enzyme combination in the comprehensive treatment of periodontal disease: a systematic review. Parodontologiâ. 2025; [Crossref]
2- Consorti G, Monarchi G, Paglianiti M, Betti E, Balercia P. Reduction of Post-Surgical Facial Edema Following Bromelain and Coumarin Intake in Traumatology: A Prospective Study with 100 Patients. JCM. 2024;13(4):922 [Crossref]
3- Mirbagheri Z, Mohammadzadeh M, Labbaf S, Behzad T, Fakhar A, Majumdar D. Green Synthesis of Silver Nanocarriers Using Aloe Vera Extract: Exploring Their Bioactive Potential for Wound Healing Applications. Journal of Nanotechnology. 2025;2025(1) [Crossref]
4- Acipinar Ş, Ozkaraca M, Okkay U, Mendil A. Effects of bromelain, melatonin, and thymoquinone on neutrophil extracellular trap formation and macrophage polarization in experimental periodontitis. J Appl Oral Sci. 2026;34 [Crossref]
5- Recinella L, Pinti M, Libero M, Di Lodovico S, Veschi S, Piro A, Generali D, Acquaviva A, Nilofar N, Orlando G, Chiavaroli A, Ferrante C, Menghini L, Di Simone S, Brunetti L, Di Giulio M, Leone S. Beneficial Effects Induced by a Proprietary Blend of a New Bromelain-Based Polyenzymatic Complex Plus N-Acetylcysteine in Urinary Tract Infections: Results from In Vitro and Ex Vivo Studies. Antibiotics. 2024;13(10):985 [Crossref]
6- Colletti A, Procchio C, Pisano M, Martelli A, Pellizzato M, Cravotto G. An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study. Nutrients. 2024;16(6):784 [Crossref]
7- Kansakar U, Trimarco V, Manzi M, Cervi E, Mone P, Santulli G. Exploring the Therapeutic Potential of Bromelain: Applications, Benefits, and Mechanisms. Nutrients. 2024;16(13):2060 [Crossref]