Submitted: 10 Feb 2016
Accepted: 02 Apr 2016
ePublished: 09 Oct 2018
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

J Periodontol Implant Dent. 2016;8(1): 33-36.
doi: 10.15171/jpid.2016.006
  Abstract View: 179
  PDF Download: 200

Research Article

Evaluation of Relationship between Streptococcus mutans, Dental Caries and IL-1α and IL-6

Hossein Eslami 1, Firoz Pouralibaba 1, Roya Rezaii Sepas 2, Ali Zarandi 3*

1 Assistant Professor, Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
2 Private Practice, Tabriz, Iran
3 Assistant Professor, Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author; E-mail: dr.alizarandi@gmail.com


Background and aims. Streptococcus mutans is an important species in oral microflora and its components have been found to stimulate production of proinflammatory cytokines in dental caries. The aim of this study was to evaluate proinflammatory cytokines (IL-1α and IL-6) in patients with S. mutans.

Materials and methods. Seventy samples were selected during pulpectomy and investigated for the presence of IL-1α and IL-6 by ELISA. The results were analyzed by t-test (α = 0.05).

Results. The results showed higher mean concentrations of IL-6 and IL-1a in inflamed pulpal tissues in subjects with dental caries associated with S. mutans, compared with intact pulpal tissue samples; these higher means were statistically significant in all cases (P<0.05).

Conclusion. The results of this study suggested relations between the production of IL1-a and IL-6 in dental caries caused by S. mutans. 

Keywords: Dental caries, interleukin-6, interleukin-1α, inflammation, Streptococcus mutans
First Name
Last Name
Email Address
Security code

Abstract View: 179

Your browser does not support the canvas element.

PDF Download: 200

Your browser does not support the canvas element.