Abstract
Background and aims. Along with conventional periodontal therapy, subginigval application of platelet-rich plasma
(PRP) may provide more effective improvements in clinical parameters due to the presence of multiple growth factors. The
aim of this double-blind, split-mouth, randomized study was to evaluate the adjunctive use of PRP with scaling and root
planing (SRP) in the treatment of chronic periodontitis.
Materials and methods. A total of 87 non-smokers suffering from moderate to severe chronic periodontitis were selected.
Parameters were probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI) and modified
bleeding index (mBI). After full-mouth SRP the sites were randomly divided into experimental sites receiving subgingival
application of autologous PRP and controls treated with placebo gel. Measurements were recorded at baseline, 3 months
and 6 months. Paired t-test was used to compare response to treatment between the two sites.
Results. Statistically significant changes in parameters were seen in both groups from baseline to 6 months. Inter-group comparison
revealed significantly more clinical attachment gain for the experimental group (P>0.05). The mean CAL gain was
2.40±0.4 mm for control sites and 2.68±0.5 mm for experimental sites.
Conclusion. This study supports the use of PRP during nonsurgical debridement of periodontal pockets measured 6 months
after SRP.