Abstract
Background: This study investigates the impact of bone improvement techniques on bone loss maintenance after tooth extraction, specifically focusing on the combination of lovastatin and ridge preservation strategies. These strategies can reduce bone resorption and improve alveolar bone quality despite the potential risks associated with high-dose statins. Methods: 20 healthy patients undergoing bone grafting after tooth extraction in the anterior region of the maxilla were randomly divided into A and B groups. After non-invasive extraction, group A received a synthetic bone graft substitute combined with lovastatin, while group B received a synthetic bone graft alone. The graft was placed into the tooth socket, covered with a collagen cone for support. After six months, a histomorphometry analysis assessed horizontal changes, using with clipper in the area compared to pre-treatment clinical measurements. Results: In this research involving 40 areas, a histological analysis showed that the bone formation rate was 51.69% in the group receiving only the synthetic bone graft substitute. The group treated with the synthetic bone graft plus 10 mg of Lovastatin 40mg had a higher rate of 60.79%. The analysis also indicated that the synthetic bone graft only group had a mean of 1.70 remaining particles, compared to 0.4844 in the Lovastatin group, highlighting the significant impact of Lovastatin. Additionally, the ridge width was less in the Lovastatin group, and there was no evidence of inflammation or a foreign body reaction. Conclusion: According to the study, lovastatin shows promise in enhancing osteogenesis, narrowing the ridge, and decreasing residual connective tissue, all while avoiding inflammation and foreign body reactions.