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J Adv Periodontol Implant Dent. Inpress.
doi: 10.34172/japid.025.3895

Original Article

Effect of nonsurgical periodontal therapy on the eradication of gastric Helicobacter pylori infection: A randomized clinical trial

Parichehr Behfarnia* ORCID logo, Reza Birang ORCID logo, Shirin Rostami ORCID logo, Vahid Sebghatollahi ORCID logo
*Corresponding Author: Email: dr.pbehfarnia@gmail.com

Abstract

Background. This study aimed to assess the effectiveness of a combine systemic and nonsurgical periodontal treatments, in eradicating gastric Helicobacter pylori (H. pylori) in patients having the bacterium within their subgingival biofilm. Methods. This randomized clinical trial (RCT) investigated 102 patients diagnosed with peptic ulcer or dyspepsia and positive stomach test for H. pylori infection (G+). Participants with negative test for oral infection received only triple therapy (G3, n = 38), and whom positive for oral infection were randomly allocated to one of two treatment regimens: A 14-day course of triple therapy (comprising antibiotics, antimicrobials, and proton pump inhibitors) alongside periodontal therapy (G1, n = 32), or triple therapy alone (G2, n = 32). The effectiveness of H. pylori eradication was assessed four weeks post-treatment using the H. pylori stool antigen (Stool Ag) test. Data analysis was performed using SPSS software version 22. Results. In the G2 and G3 groups, triple therapy achieved success rates of 52% and 84%, respectively. When periodontal therapy was integrated with triple therapy in G1 group, the success rate was 80%. Significant statistical differences were observed between the G1 and G2 groups (P = 0.037), and also between the G3 and G2 groups (P = 0.015). Conversely, no significant difference was found between the G1 and G3 groups (P > 0.05). Conclusion. Periodontal therapy has the potential to substantially increase the efficacy of H. pylori eradication regimens for gastric infections.
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Submitted: 01 Jun 2025
Revision: 26 Jul 2025
Accepted: 27 Jul 2025
ePublished: 06 Aug 2025
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