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J Adv Periodontol Implant Dent. 2024;16(2): 116-122.
doi: 10.34172/japid.2024.017
  Abstract View: 93
  PDF Download: 51

Research Article

Effect of atorvastatin gel in non-surgical treatment of peri-implant mucositis: A randomized controlled clinical trial

Azin Khorramdel 1 ORCID logo, Katayoun Mogharrab Alile 2* ORCID logo, Yousef Kananizadeh 3 ORCID logo, Seyed Amin Mousavi 4 ORCID logo, Fatima Molavi 5 ORCID logo

1 Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
2 Dentist, Faculty of Dentistry, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran
3 Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran
4 Department of Prosthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
5 Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Katayoun Mogharrab Alile, Email: Katayoun.m.98@gmail.com

Abstract

Background. Peri-implant diseases, such as peri-implant mucositis and peri-implantitis, are inflammatory conditions caused by biofilms that can lead to the loss of surrounding soft tissues and bone. The most effective treatment involves non-surgical mechanical debridement to remove plaque, but other treatment modalities have shown limited success. This study investigated the anti-inflammatory and immunomodulatory effects of atorvastatin (ATV) gel as an additional treatment for peri-implant mucositis.

Methods. In this double-masked, randomized clinical trial, 49 patients with peri-implant mucositis were randomly divided into two treatment groups: mechanical debridement (MD)+placebo or MD+ATV gel. At baseline, 1 month, and 3 months after the intervention, periodontal parameters, including probing depth (PD), bleeding on probing (BOP), clinical attachment level (CAL), and pain on probing (POP), were measured. Data were analyzed using independent t-test and paired t-test.

Results. Statistically significant improvements in CAL and POP were observed from baseline to each time point throughout the study period (P≤0.001). PD and BOP were statistically significant 1 month and 3 months after the intervention, respectively (P<0.05).

Conclusion. The clinical parameters associated with peri-implant mucosal inflammation further improved when ATV gel was used with MD.

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Submitted: 20 Feb 2024
Accepted: 21 Jul 2024
ePublished: 11 Sep 2024
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