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J Adv Periodontol Implant Dent. 2023;15(1): 35-41.
doi: 10.34172/japid.2023.006
PMID: 37645555
PMCID: PMC10460781
Scopus ID: 85178123560
  Abstract View: 740
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Research Article

Evaluation of the antibacterial effect of hydroalcoholic extract of the galls of Quercus infectoria on Aggregatibacter actinomycetemcomitans

Zohreh Tabibzadeh Noori 1 ORCID logo, Mohadese Tabatabaei Rad 2* ORCID logo, Mojdeh Hakemi Vala 3, Mehrdad Karimi 4, Azadeh Esmaeil Nejad 1

1 Department of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Science, Tehran, Iran
2 Department of Pediatrics, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran
3 Department of Microbiology, Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran
4 Faculty of Traditional Medicine, Tehran University of Medical Science, Tehran, Iran
*Corresponding Author: Email: mohadesetabatabaei@gmail.com

Abstract

Background. Aggregatibacter actinomycetemcomitans (Aa) plays a vital role in some destructive forms of periodontitis. While mechanical and chemical plaque control is the first step in periodontitis treatment, side effects of adjunctive chemical agents such as chlorhexidine (CHX) mouthwash have led to the application of natural alternatives with minimal side effects. Therefore, this study evaluated the antibacterial effect of the hydroalcoholic extract of Quercus infectoria (Qi) galls on Aa in vitro.

Methods. The hydroalcoholic extract of Qi was obtained by the maceration method, and Aa bacterial strain was cultured. The inhibition zone diameter was measured through the agar well diffusion method. Also, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values were determined by the broth microdilution method. All the experiments were repeated three times. 0.2% CHX was used as a control.

Results. The inhibition zone diameter of Aa increased with increasing concentration of Qi extract. While MIC and MBC values for CHX were 0.0039 and 0.0078 mg/mL, respectively, both MIC and MBC values of the Qi extract for this bacterium were similar, i.e., 2.5 mg/mL, which was significantly higherd.

Conclusion. Since other in vivo studies have confirmed the other properties of this extract and its safety in terms of cytotoxicity and mutagenicity, hydroalcoholic extract of Qi may be used in mouthwashes or local delivery systems to affect periodontal biofilm.

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Submitted: 25 Jan 2022
Revision: 20 Dec 2022
Accepted: 10 Jan 2023
ePublished: 05 Apr 2023
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