J Adv Periodontol Implant Dent. 2021;13(2): 56-60.
doi: 10.34172/japid.2021.015
  Abstract View: 161
  PDF Download: 126

Research Article

Effect of tetracycline on IL-1β and IL-6 levels of the peri-implant sulcular fluid

Amir Mehrabi 1 ORCID logo, Ramin Negahdari 1* ORCID logo, Feridoun Parnia 1, Alireza Garjani 2

1 Department of Prosthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Pharmacology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran


Background. Inflammation in the implant-abutment interface is one of the main factors that can reduce implant stability. Therefore, this study investigated the effect of chlorhexidine, tetracycline, saliva, and a dry environment on the interleukin IL-1β and interleukin IL-6 levels of the gingival groove fluid at the implant-abutment interface.Methods. Twenty-four (10 men and 14 women) patients referred to the Faculty of Dentistry for implant treatment, who met the inclusion criteria, were examined. Four different materials were used in each implant, including 2% chlorhexidine, 3% tetracycline, saliva, and a dry medium. Each test material was placed inside the implant screw during the anchorage session, and the healing screw was closed. Patients were then sampled in three implantation sessions and one month after prosthesis delivery. Interstitial fluid groove was used for sampling after cleaning the mouth (half an hour after three minutes of thorough brushing). The data were analyzed with SPSS 20 using ANOVA and relevant post hoc tests.Results. There was a significant difference in the mean IL-6 and IL-1β levels between the four materials (P<0.05). IL-6β levels were similar in tetracycline and chlorhexidine but significantly higher than in saliva and the dry environment (P<0.05). IL-6 and IL-1β levels in the saliva were significantly higher than in the dry environment (P<0.05).Conclusion. The use of tetracycline at the junction of implant and abutment reduces the inflammatory cytokines IL-6 and IL-1β.
Keywords: Antiseptic, gingival crevicular fluid, IL-1β, IL-6, implant
First Name
Last Name
Email Address
Security code

Abstract View: 162

Your browser does not support the canvas element.

PDF Download: 126

Your browser does not support the canvas element.

Submitted: 18 Sep 2021
Revision: 06 Nov 2021
Accepted: 09 Nov 2021
ePublished: 17 Nov 2021
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)