Submitted: 27 Jun 2018
Revised: 02 Aug 2018
Accepted: 30 Aug 2018
First published online: 10 Oct 2018
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J Adv Periodontol Implant Dent. 2018;10(1):18-23.
doi: 10.15171/japid.2018.004
  Abstract View: 68
  PDF Download: 70

Research Article

Effect of Non-Surgical Periodontal Treatment on Serum Albumin Levels in Patients with Chronic Periodontitis

Adileh Shirmohammadi, Masoumeh Faramarzi, Ashkan Salari, Mehrnoosh Sadighi, Amir Reza Babaloo, Zohreh Mousavi

1 Department of Periodontics, Dental School, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Periodontics, Dental School, Rasht University of Medical Sciences, Rasht, Iran
3 Private Practice, Tabriz, Iran


Background. Albumin is a protein whose serum levels decrease in inflammatory conditions such as periodontal diseases. The aim of the present study was to evaluate changes in serum albumin levels in patients with and without periodontal diseases before and after non-surgical periodontal treatment and its relationship with clinical variables of periodontal disease. Methods. Twenty patients with chronic periodontitis and 20 periodontally healthy subjects, referring to Tabriz Faculty of Dentistry, were selected for the purpose of this study. Serum albumin levels and clinical periodontal parameters (pocket depth, clinical attachment level, gingival index, bleeding index and plaque index) were determined and recorded at baseline and 3 months after non-surgical periodontal treatment. Data were analyzed with descriptive statistics (mean ± SD). Independent-samples t-test was used to compare serum albumin levels and clinical parameters between the case and control groups. Paired-samples t-test was used to compare the variables before and after treatment in the case group. Statistical significance was set at P<0.05. Results. The mean serum albumin level of patients with chronic periodontitis (3.62±0.11 mg/dL) was significantly less than that in periodontally healthy subjects (4.17±0.29 mg/dL). Three months after periodontal treatment, the serum albumin levels increased significantly (3.78±0.33 mg/dL), approaching the level in periodontally healthy subjects (P<0.05). Conclusion. Decreases and increases in serum albumin levels with periodontal disease and its treatment indicate an inverse relationship between serum albumin levels and chronic periodontitis. Key words: Albumin, chronic periodontitis, dental scaling, non-surgical inflammation, root planing.
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