J Periodontol Implant Dent. 2013;5(2): 61-65.
doi: 10.5681/jpid.2013.010
  Abstract View: 252
  PDF Download: 142

Research Article

HCMV Antibody Titer in Gingival Crevicular Fluid in Chronic Periodontitis

Vahid Esfahanian 1, Shirin Zahra Farhad 1, Mehrnaz Sadighi Shamami 2, Manoochehr Mesripour 3, Mohamadreza Ghafari 3*, Morvarid Mafi 4, Farnaz Kouchakian 5

1 Assistant professor, Department of Periodontology, Dental faculty, Isfahan (Khorasgan) branch - Islamic Azad University, Isfahan, Iran
2 Assistant professor, Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
3 Professor of Biochemistry, Department of Biochemistry, Khorasgan Islamic Azad University (Isfahan), Iran
4 Post-Graduate Student of Periodontics, Department of Periodontics, Khorasgan Islamic Azad Dental School (Isfahan), Iran
5 Post-Graduate Student of Periodontics, Department of Periodontics, Young Researchers Club, Khorasgan Branch, Islamic Azad Dental School (Isfahan), Iran
6 Private Practice
*Corresponding Author: *Corresponding Author; E-mail:, Email: Shahabgh1982@gmail.com


Background and aims. Despite available evidence for the role of herpes viruses in destructive periodontal diseases, no cause-and-effect relationship has been found to date. This study compared the titer of immunoglobulin G (IgG), immunoglobulin M (IgM) against human cytomegalovirus (HCMV) in gingival crevicular fluid between individuals with periodontitis and with healthy periodontium.

Materials and methods. Thirty samples of gingival crevicular fluid (ten from infected sites and ten from non-infected sites from ten individuals with periodontitis and ten from ten individuals with healthy periodontium) were provided. The titer of IgG and IgM were evaluated. Data was analyzed by one-way ANOVA, Kruskal-Wallis test, t-test, Duncen’s test and Pearson’s correlation coefficient.

Results. There were no statistically significant differences in the means of IgM titers of the three groups under study (P>0.05), but there were significant differences in IgG titers between the three groups (P<0.001).

Conclusion. Within the limits of the present study, it can be concluded that IgG titers against the human cytomegalovirus can increase in patients with periodontal diseases but the IgM titers do not show a significant increase in these individuals. 

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Submitted: 17 May 2012
Accepted: 12 Apr 2013
ePublished: 21 Jun 2013
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