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Submitted: 24 Aug 2010
Accepted: 11 Oct 2010
ePublished: 22 Sep 2018
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J Periodontol Implant Dent. 2010;2(2): 56-60.
  Abstract View: 143
  PDF Download: 149

Research Article

Relationship between Mast Cell Counts and Different Types of Periodontitis

Surena Vahabi 1*, Fahime Rezazadeh 2, • Sepideh Ebrahimi Movaghar 3, Bahare Nazemisalman 4

1 Assistant Professor, Department of Periodontics, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Post-graduate Student, Department of Oral Medicine, Dental School, Shiraz University of Medical Sciences, Shiraz, Iran
3 Dentist, Private Practice, Tehran, Iran
4 Post-graduate Student, Department of Pedodontics, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding Author; E-mail: isure1@gmail.com

Abstract

Background and aims. Mast cells play an important role in allergic reactions, host defense, local homeostasis, inflammation and angiogenesis. The aim of this study was to evaluate the relationship between mast cell counts and different types of periodontitis.

Materials and methods. Gingival specimens were taken from 20 moderate-to-advanced chronic and 19 moderate-toadvanced aggressive periodontal sites as case groups and 18 healthy/gingivitis sites as control group in routine periodontal flap and crown lengthening procedures. All the specimens were stained by toluidine blue for mast cell counting and hematoxylin/eosin to assess inflammation. Inflammatory and mast cells were assessed in 5-micron sections by two observers 3 times, utilizing light microscopy at ×100 and ×400 magnification. ANOVA and t-test were used to analyze data. Statistical significance was defined at α=0.05.

Results. Mast cell counts were higher in chronic versus aggressive periodontitis and healthy/gingivitis cases (P = 0.000). The aggressive periodontitis cases did not demonstrate higher counts of mast cells as compared to healthy/gingivitis cases (P >0.05). There was no relationship between mast cell counts and degree of inflammation in the three groups.

Conclusion. The present study indicated higher mast cell counts in the chronic periodontitis sites compared to other sites. The results of this study suggest that further studies are necessary to simultaneously evaluate dynamic aspects of host defense and other aspects of immune system.

Keywords: Aggressive, chronic, inflammation, mast cells, periodontal disease
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