Submitted: 26 Sep 2018
Revised: 24 Nov 2018
Accepted: 04 Dec 2018
First published online: 19 Jan 2019
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J Adv Periodontol Implant Dent. 2018;10(2):50-57.
doi: 10.15171/japid.2018.009
  Abstract View: 27
  PDF Download: 35

Original Article

Prevalence of Porphyromonas gingivalis fimbriae A genotypes II and IV in patients with chronic periodontitis and atherosclerosis 

Abstract

Background and aim: Atherosclerosis is known as one of the chronic diseases with high prevalence in the human species. Many studies have elucidated the relationship between this disease and chronic periodontitis caused by Porphyromonas gingivalis(P.g) bacterium. The aim of this study was to investigate the prevalence of P.g fimbriae A (fimA) genotypes II and IV in patients with periodontitis and atherosclerosis. Methods: This cross-sectional study investigated the frequency of P.g II and IV genotypes in the subgingival plaque specimens of 42 subjects in three experimental groups periodontitis (A), atherosclerosis (B), periodontitis + atherosclerosis (C) and aortic wall specimens obtained from 30 patients (Groups B and C) by the PCR technique. Results: P.g bacterium was seen among 46.6% of patients with chronic periodontitis. The same bacterium was not found in aortic wall specimens of patients with chronic periodontitis (Group C) and there was only one P.g-positive aortic wall specimen (7.7%) among the patients with healthy periodontium (Group B). Genotypes II and IV were not observed in any specimen. Conclusion: The results of statistical analysis showed no significant correlation between the prevalence of P.g bacterium and genotypes II and IV in the subgingival plaques and the incidence and severity of atherosclerosis. Key words: Chronic periodontitis, atherosclerosis, Porphyromonas gingivalis, fimbriae, genotypes II and IV.
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