Submitted: 15 Jul 2014
Accepted: 23 Jan 2015
ePublished: 08 Oct 2015
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J Periodontol Implant Dent. 2015;7(1): 7-14.
doi: 10.15171/jpid.2015.002
  Abstract View: 418
  PDF Download: 311

Research Article

The Effects of Obesity on Local and Circulating Levels of Tumor Necrosis Factor-α and Interleukin-6 in Patients with Chronic Periodontitis

Oğuz Kose 1*, Varol Canakcı 2, Cenk Fatih Canakcı 3, Abdulkadir Yıldırım 4, Eda Kermen 3, Taner Arabacı 3, Adem Gungor 5

1 Department of Periodontology, Faculty of Dentistry, Recep Tayyip Erdogan University, Rize, Turkey
2 Faculty of Dentistry, Ataturk University, Erzurum, Turkey
3 Department of Periodontology, Faculty of Dentistry, Atatürk University, Erzurum, Turkey
4 Department of Biochemistry, Ataturk University Faculty of Medicine, Erzurum, Turkey
5 Department of Endocrinology, School of Medicine, Ataturk University Erzurum, Turkey
*Corresponding Author; E-mail: dtoguzkose61@hotmail.com


Background and aims. The aim of this study was to evaluate the possible effects of obesity on the local (salivary) and systemic TNF-α and IL-6 levels in patients with chronic periodontitis (CP).

Materials and methods. This study included 88 subjects assigned to four groups of 22 subjects each, as follows: group O+P+ (patients with obesity and CP), group O-P+ (patients with normal weight and CP), group O+P- (periodontally healthy patients with obesity), and the control group, group O-P- (periodontally healthy patients with normal weight). Serum and salivary samples were obtained a week before the recording of clinical periodontal parameters. Local and systemic TNF-α and IL-6 levels were determined biochemically.

Results. In serum and saliva, both TNF-α and IL-6 levels were the lowest in O-P- group (P < 0.05). The highest TNF-α and IL-6 levels were observed in O+P+ group, while only IL-6 levels were statistically significant (P < 0.05).

Conclusion. Obesity upregulated the salivary and serum levels of TNF-α and IL-6. In patients with periodontitis, who were also obese, the serum and saliva levels of IL-6 were significantly high. Obesity might play a destructive and provocative role in the pathogenesis of periodontitis by negatively affecting IL-6 levels.

Keywords: Interleukin, obesity, periodontitis, saliva, tumor necrosis factor
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