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Submitted: 18 Mar 2018
Revision: 20 Jun 2018
Accepted: 02 Sep 2018
ePublished: 10 Oct 2018
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J Adv Periodontol Implant Dent. 2018;10(1): 8-12.
doi: 10.15171/japid.2018.002
  Abstract View: 173
  PDF Download: 138

Research Article

Comparative evaluation of IL-17 and TGF-β expression in tissues of patients with chronic periodontitis and healthy individuals using real-time PCR

Kazem Fatemi 1, Seyed Abdolrahim Rezaee 2*, Amir Moeintaghavi 3, Farid Shiezadeh 4, Golnaz Dadpour 4, Mohammad Rasoul Asadinezhad 4, Nahid Nasrabadi 4

1 Dental Research Center, Mashhad University of Medical Sciences, Iran
2 Immunology Research Center, Inflammation and Inflammatory Diseases Division, Mashhad University of Medical Sciences, Mashhad, Iran
3 Maxillofacial Disease Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4 Department of Periodontics, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Background. The present study aimed to determine the association between periodontal disease and the Th17/Treg balance by examining the genetic expression of IL-17 and TGF-β, which influence incidence and suppression of inflammation. Methods. In this case-control study, samples were collected in a randomized and task-oriented order. Thirty-seven patients referred to professional periodontology clinics in Mashhad and the Periodontology Department of the Mashhad Dentistry Faculty for periodontal (case) or crown-length (control) surgery was enrolled. IL-17 and TGF-β gene expression indices were measured in tissue samples by real-time polymerase chain reaction. Results. The IL-17 gene expression index was higher in the case group (2.68±0.91) than in the control group (1.68±0.41), but this difference was not significant. The TGF-β gene expression index was significantly higher in the case group (54.42±7.88) than in the control group (24.12±3.38). Conclusion. L-17 and TGF-β expression is increased in chronic periodontitis patients, but TGF-β plays a more important role in periodontal inflammation in patients with chronic periodontitis. Further studies of the roles of Th17 and Treg cells are warranted.
Keywords: Chronic periodontitis, Th17 cells, TGF-beta, regulatory T Cells, reverse transcriptase polymerase chain reaction
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