Abstract
Regenerating a functional tooth with supporting bone and periodontal structures is a promising ambition. Tooth germ-derived stem cells from unerupted teeth recreate natural tooth formation. Harnessing these cells could shift oral rehabilitation, reducing reliance on implants and jawbone reconstruction. This editorial spotlights recent research on cell sourcing, scaffold optimization, signaling pathways, and clinical explorations, suggesting restoration of natural tooth biology in edentulous areas. The promise extends beyond severe cases: it could redefine tooth replacement for patients missing teeth, advancing regenerative dentistry toward biologically authentic solutions. Key words: Bone regeneration, dentistry, oral health, regeneration, regenerative medicine, stem cells, tooth germ.