Ayla Bahramian
, Farzaneh Pakdel
, Solmaz Pourzare Mehrbani
, Ehsan Golchin
, Ensiyeh Maljaei
, Maryam Hosseinpour Sarmadi
, Tara Deljavanghodrati
, katayoun katebi
*
Abstract
Background: Desquamative gingivitis is an immunological chronic disease which is considered precancerous and has the potential to develop to squamous cell carcinoma. Carcinoembryonic Antigen (CEA), a common tumor marker, increases in many cancers. The aim of the present study was to compare salivary carcinoembryonic antigen in desquamative gingivitis before and after topical corticosteroid therapy. Methods: This case-control study was conducted in oral and maxillofacial medicine department of Tabriz faculty of Dentistry. Twenty patients with desquamative gingivitis in oral lichen planus background, were selected as case group and 20 healthy individuals as control group. Desquamative gingivitis lesions were confirm with biopsies. Salivary samples were obtained from both groups. Second salivary samples were collected from the case group after a course of topical corticosteroid therapy. Salivary CEA levels were measured by monobind kit with ELISA method. Independent and paired t-tests were used to analyze the data in SPSS 24. P<0.05 was considered statistically significant. Results: Before treatment, CEA levels were significantly higher in case group (174.06±95.55) than control group (55.66±41.26 ng/ml) (P<0.001). Salivary CEA levels in the case group were significantly lower after the treatment (96.77±66.25ng/ml) than CEA levels before the treatment (174.06±95.55 ng/ml) (P<0.001). Conclusion: The results of this study showed that after topical corticosteroid therapy, CEA levels significantly reduced in patients with desquamative gingivitis.