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J Adv Periodontol Implant Dent. Inpress.
doi: 10.34172/japid.025.3543
  Abstract View: 3

Original Article

"A pilot study and histological examination of xenograft and autogenous bone combinations with i-PRF in guided bone regeneration"

Saurabh Kamat ORCID logo, Senthil Murugan M ORCID logo, Edlyn Rodrigues ORCID logo, Jochima Eudora Cota* ORCID logo, Vikas Dhupar ORCID logo, Francis Akkara ORCID logo
*Corresponding Author: Email: jochimacota@gmail.com

Abstract

Background. This study aims to evaluate the impact of different regenerative biomaterial combinations on bone quality and implant stability in Guided Bone Regeneration (GBR).

Methods. A pilot study was conducted from September 2020 to October 2023, comparing bone regeneration quality and implant stability following GBR using three composite graft combinations. A total of 47 patients participated in the study, divided into three experimental groups: Group A (deproteinized cancellous bovine bone [xenograft] with injectable platelet-rich fibrin [i-PRF]), Group B (xenograft with autogenous bone graft in 2:1 ratio with i-PRF), and Group C (xenograft with autogenous bone graft in 1:1 ratio with i-PRF). The implant stability quotient (ISQ) was measured at the time of implant placement. Crestal bone biopsies were performed.

Results. The study found that Group C, utilizing a 1:1 ratio of xenograft and autogenous graft with i-PRF, achieved the highest new bone formation (65.83%) and demonstrated moderately high vascularization and osteoclastic activity, indicative of good remodeling potential. ISQ measurements for all groups indicated good primary stability of implants, ranging between 55 to 65 at the time of placement.

Conclusions. Combining xenograft with autogenous graft in a 1:1 ratio, along with i-PRF, yields optimal outcomes for new bone formation in GBR procedures. However, further research is needed to address limitations associated with i-PRF, such as lack of rigidity and faster degradation, to enhance its application in GBR procedures.

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Submitted: 03 May 2024
Revision: 04 Jun 2025
Accepted: 10 Jun 2025
ePublished: 28 Jun 2025
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