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J Adv Periodontol Implant Dent. 2023;15(2): 74-79.
doi: 10.34172/japid.2023.023
PMID: 38357337
PMCID: PMC10862042
  Abstract View: 402
  PDF Download: 342

Research Article

Clinical evaluation of chitosan/polycaprolactone nanofibrous scaffolds releasing tetracycline hydrochloride in periodontal pockets of patients with chronic periodontitis

Janet Moradi Haghgoo 1 ORCID logo, Parviz Torkzaban 1, Parisa Hashemi 1* ORCID logo, Rana Sarvari 2, Sana Hashemi 3, Elahe Fakhri 4, Behnaz Alafchi 5

1 Department of Periodontics, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran
2 Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Prosthodontics, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
4 Dental and Periodontal Research Center, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
5 Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
*Corresponding Author: Parisa Hashemi, Email: parisah2773@gmail.com

Abstract

Background. The role of bacteria in the initiation and progression of periodontitis has led to a great interest in using antibiotics to suppress pathogenic microbiota. Considering the drawbacks of systemic antibiotics’ application, local delivery systems directly in the periodontal pocket can be helpful. Therefore, the effect of an efficient tetracycline-loaded delivery system was investigated on the clinical parameters of periodontitis.

Methods. In this clinical trial with a split-mouth design, 10 patients with periodontitis with pocket depths≥5 mm were included. After scaling and root planing (SRP) for all the patients, one side of the mouth was randomly considered as the control group, and on the other side, chitosan/polycaprolactone (PCL) nanofibrous films containing tetracycline (5%) were placed in pockets of 5 mm and deeper. Clinical measurements of pocket probing depth (PPD), clinical attachment loss (CAL), and bleeding on probing (BOP) indices were made at the beginning and after 8 weeks of intervention. PPD, CAL, and BOP parameters were compared between the control and test groups before and after the intervention with paired t tests using SPSS 24. The significance level of the tests was considered at P<0.05.

Results. The mean PPD, CAL, and BOP in both the control (SRP) and test (LDDs) groups decreased after 8 weeks. A significant difference was detected in reducing PPD, BOP, and CAL after 8 weeks in 5-mm pockets, and the mean values were higher in the test group than in the control (P<0.05).

Conclusion. The local drug delivery system using chitosan/PCL nanofibrous films containing tetracycline can effectively control periodontal diseases by reducing pocket depth and inflammation and improving CAL without offering side effects, although further evaluations are needed.

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Submitted: 26 Oct 2023
Revision: 26 Nov 2023
Accepted: 30 Nov 2023
ePublished: 03 Dec 2023
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