Abstract
Background: The purpose of this research was to evaluate the clinical characteristics of pain and wound-healing and serological inflammatory markers after full-mouth implantation in one session compared to several sessions. Materials: A single-blind clinical trial on 20 patients (n=10) receiving full-mouth implants was conducted. Patients were randomly divided into two groups. The first group was operated under general anesthesia in one session and the second group, in multi-sessions. Inflammation level was evaluated through WBC and serum CRP pre and post-surgery by a blood test. Pain and early wound healing assessment was conducted after surgery with VAS and EHS indicators, respectively. Comparison of serological and clinical parameters was done by Repeated Measures ANOVA and sidak and U-Man-Whitney test respectively using SPSS.20 software. Results: The CRP level 48 hours post-surgery was not different in two groups; however, 7 days after treatment, it was more in multi-session group than single-session. The WBC was not different between groups in evaluated periods. Serum levels of WBC and CRP increased 48 hours post-surgery and decreased 7 days later. EHS showed no difference between the two groups in the three investigated periods. The amount of VAS at 24 hours, 48 hours and 7 days post-surgery was higher in multi-session surgery than in one-session. In both groups, VAS was not different at 24 and 48 hours post-surgery and decreased over 7 days. Conclusion: Full-mouth implant surgery under general anesthesia in one-session causes less inflammation and pain post-surgery while presenting the same wound-healing process as the multi-session surgery.