Abstract
Background. This study compared tumor necrosis factor-α (TNF-α) and interlukin-1β (IL-1β) concentrations in the saliva and gingival crevicular fluid (GCF) of patients with gingivitis and periodontitis and healthy individuals.
Methods. In this study, 45 patients (n=15 in each group) were selected, and the concentrations of inflammatory cytokines TNF-α and IL-1β in their salivary and GCF samples were measured using the ELISA method. Shapiro-Wilk test, one-way analysis of variance, post hoc Bonferroni test, and Pearson’s correlation coefficient were used to analyze the data.
Results. According to the results of the post hoc Bonferroni test, the mean salivary and GCF levels of TNF-α and IL-1β in healthy individuals were significantly lower than those with periodontitis (P<0.05) and gingivitis (P<0.05). Also, the mean levels of TNF-α and IL-1β in the saliva and GCF of patients with periodontitis were significantly higher than patients with gingivitis (P<0.05).
Conclusion. Based on the findings of the study, saliva, like GCF, can be considered a source for monitoring the markers related to periodontal disease. However, more uniformity was observed in GCF than in saliva in terms of alignment of markers secretion.