J Adv Periodontol Implant Dent. 2022;14(1): 1-6.
doi: 10.34172/japid.2022.001
  Abstract View: 48
  PDF Download: 9

Research Article

Is netrin-1 a reliable inflammatory marker for periodontitis?

Sarah Yasser Abdulfattah 1 ORCID logo, Azza Abdel Baky Baiomy 2 ORCID logo, Jilan Mohammed Youssef 1* ORCID logo

1 Department of Oral Medicine, Periodontology, Diagnosis and Oral Radiology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
*Corresponding Author: Jilan Mohammed Youssef, E-mail: , Email: Jilan_youssef@mans.edu.eg


Background. The current study tested netrin-1 as a reliable inflammatory marker of periodontal disease.

Methods. Gingival crevicular fluid (GCF) samples were taken at baseline from 30 systemically healthy individuals. Fifteen subjects had stage II grade A or B periodontitis, and 15 were periodontally and clinically healthy. Whole-mouth periodontal parameters [probing depth (PD), clinical attachment loss (CAL), plaque index (PI), and gingival index (GI)] were recorded. The GCF samples were re-collected, and clinical parameters were re-recorded after six weeks following full-mouth scaling and root planing (SRP) in the periodontitis group.

Results. Netrin-1 GCF levels were significantly lower in periodontitis patients than periodontally healthy individuals at baseline with a significant increase in netrin-1 GCF levels after SRP (P<0.05).

Conclusion. Netrin-1 may have a significant role in the inflammatory process of chronic periodontitis; thus, it could be a promising anti-inflammatory marker in periodontal disease.

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Submitted: 21 Nov 2021
Revision: 16 Jan 2022
Accepted: 17 Jan 2022
ePublished: 24 Jan 2022
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