J Adv Periodontol Implant Dent. 2021;13(1): 43-47.
doi: 10.34172/japid.2021.003
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Antibacterial agent-releasing scaffolds in dental tissue engineering

Zahra Gholami 1 ORCID logo, Shirin Hasanpour 1, Samira Sadigh 1, Sana Johari 1, Zahra Shahveghar 1, Kosar Ataei 1, Eelahe Javari 1, Mahsa Amani 1, Leila Javadi Kia 1, Zahra Delir Akbari 1, Zahra Nazari 1, Solmaz Maleki Dizaj 2* ORCID logo, Yashar Rezaei 2* ORCID logo

1 Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
2 Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


It seems quite challenging in tissue engineering to synthesize a base material with a range of essential activities, including biocompatibility, nontoxicity, and antimicrobial activities. Various types of materials are synthesized to solve the problem. This study aimed to provide the latest relevant information for practitioners about antibacterial scaffolds in dental tissue engineering. The PubMed search engine was used to review the relevant studies with a combination of the following terms as search queries: tissue engineering, scaffolds, antimicrobial, dentistry, dental stem cells, and oral diseases. It is noteworthy to state that only the terms related to tissue engineering in dentistry were considered. The antimicrobial scaffolds support the local tissue regeneration and prevent adverse inflammatory reactions; however, not all scaffolds have such positive characteristics. To resolve this potential defect, different antimicrobial agents are used during the synthesis process. Innovative methods in guided tissue engineering are actively working towards new ways to control oral and periodontal diseases.
Keywords: Antimicrobial agents, Endodontics, Oral diseases, Pediatric dentistry, Periodontitis, Scaffolds, Stem cell, Tissue engineering
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