Omar Khashaba
1 
, Atef Alasfar
2, Enas Ahmed Elgendy
3* , Bassant Mowafey
41 Professor of Oral Medicine, Periodontology, Oral Diagnosis, and Oral radiology Department, Faculty of Oral and Dental Medicine, Mansuora University, Egypt
2 M.S.C, Faculty of Oral and Dental Medicine, Mansuora University, Egypt
3 Professor of Oral Medicine, Periodontology, and Oral Diagnosis Department, Faculty of Oral and Dental Medicine, Kafr El-Sheikh University, Egypt
4 Lecturer of Oral Diagnosis and Oral Radiology, Faculty of Oral and Dental Medicine, Mansuora University, Egypt
Abstract
Background. The present study aimed to assess the clinical and radiographic effect of strontium ranelate and metal-substituted hydroxyapatite as bone graft materials on treating chronic periodontitis among diabetes mellitus patients.
Methods. A randomized split-mouth study was conducted on 20 sites in 10 controlled type II diabetic patients suffering from chronic periodontitis. After phase I therapy, the sites were randomly allocated by a computer-generated table into two groups. Group 1: A mucoperiosteal flap was elevated in 10 sites, followed by the placement of strontium ranelate mixed with Gengigel. Group 2: A mucoperiosteal flap was elevated in 10 opposite sites, followed by the placement of metal-substituted hydroxyapatite mixed with Gengigel. Clinical parameters were assessed at baseline and 3- and 6-month intervals. Cone-beam computed tomography (CBCT) was used at baseline and after six months to assess bone gain.
Results. The two treatment modalities resulted in a statistically significant reduction in clinical parameters at the 3- and 6-month intervals compared to the mean baseline value. Intergroup comparison showed a significant reduction in probing pocket depth and clinical attachment loss in group 1 compared to group 2. Comparison of the two sides by CBCT showed a significant increase in the alveolar bone height in the SR group than the metal-substituted hydroxyapatite group.
Conclusion. Clinical and radiographic results showed a significant improvement in the two groups and provided evidence that strontium ranelate is promising in treating periodontal diseases.