Submitted: 04 Oct 2020
Revision: 15 Nov 2020
Accepted: 15 Nov 2020
ePublished: 10 Dec 2020
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J Adv Periodontol Implant Dent. 2020;12(2): 51-57.
doi: 10.34172/japid.2020.015
  Abstract View: 294
  PDF Download: 192

Original Article

Clinical and radiographic diagnostic study of strontium ranelate and metal-substituted hydroxyapatite bone graft materials in diabetes mellitus with chronic periodontitis

Omar Khashaba ORCID logo, Atef Alasfar, Enas Ahmed Elgendy* ORCID logo, Bassant Mowafey


Background. The present study aimed to assess the clinical and radiographic effect of strontium ranelate and metal-substituted hydroxyapatite as bone graft materials on treating chronic periodontitis among diabetes mellitus patients.
Methods. A randomized split-mouth study was conducted on 20 sites in 10 controlled type II diabetic patients suffering from chronic periodontitis. After phase I therapy, the sites were randomly allocated by a computer-generated table into two groups. Group 1: A mucoperiosteal flap was elevated in 10 sites, followed by the placement of strontium ranelate mixed with Gengigel. Group 2: A mucoperiosteal flap was elevated in 10 opposite sites, followed by the placement of metal-substituted hydroxyapatite mixed with Gengigel. Clinical parameters were assessed at baseline and 3- and 6-month intervals. Cone-beam computed tomography (CBCT) was used at baseline and after six months to assess bone gain.
Results. The two treatment modalities resulted in a statistically significant reduction in clinical parameters at the 3- and 6-month intervals compared to the mean baseline value. Intergroup comparison showed a significant reduction in probing pocket depth and clinical attachment loss in group 1 compared to group 2. Comparison of the two sides by CBCT showed a significant increase in the alveolar bone height in the SR group than the metal-substituted hydroxyapatite group.
Conclusion. Clinical and radiographic results showed a significant improvement in the two groups and provided evidence that strontium ranelate is promising in treating periodontal diseases.
Keywords: Chronic Periodontitis, Cone Beam Computed Tomography, Diabetes Mellitus, Metal-substituted hydroxyapatite, Periodontal flap, Strontium Ranelate
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