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Submitted: 18 Mar 2020
Revision: 24 Apr 2020
Accepted: 25 Apr 2020
ePublished: 25 Apr 2020
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J Adv Periodontol Implant Dent. 2020;12(1): 39-44.
doi: 10.34172/japid.2020.006
  Abstract View: 82
  PDF Download: 54

Research Article

Association of haptoglobin and natural resistance-associated macrophage protein 1 alleles with heme-consuming periodontal pathogens in chronic periodontitis and peri-implantitis: A pilot study

Mahdi Kadkhodazadeh 1 ORCID logo, Ahmad Reza Ebadian 2 ORCID logo, Zahra Alizadeh Tabari 3 * ORCID logo, Reza Amid 4 ORCID logo, Anahita Moscowchi 4 ORCID logo

1 Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Private Practice, Tehran, Iran
3 Department of Periodontics, Dental School, Qazvin University of Medical Sciences, Qazvin, Iran
4 Department of Periodontics, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract

Background. This study aimed to assess the association of haptoglobin (HP) and natural resistance-associated macrophage protein 1 (NRAMP1) alleles with the presence of heme-consuming periodontal pathogens in a group of Iranian patients with chronic periodontitis and peri-implantitis.

Methods. This cross-sectional study evaluated 69 eligible chronic periodontitis and peri-implantitis patients selected from Shahid Beheshti Dental School. The periodontally diseased individuals had at least three teeth with clinical attachment loss of ≥3 mm and a probing pocket depth (PPD) of ≥3 mm in at least two quadrants. Peri-implant PPD of at least one site was ≥5 mm with or without suppuration and bleeding on probing. A plaque index of >20% and a radiographic crestal bone loss was present in at least one site around the implant. The paper point method was used for sampling from the deepest periodontal/peri-implant pocket of each tooth or implant for the DNA checkerboard hybridization technique. Statistical analyses were performed with PASW Statistics 18.0. The variables were presented as absolute and relative frequencies (%).

Results. An Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) score of 1–2 was 5.8 times more frequent in HP 2, rs1723540 G, and rs2276631 G alleles. A Porphyromonas gingivalis (P. gingivalis) score of 1–2 was 4.8 times more common in the subjects carrying HP 2, rs1723540 G, and rs2276631 G alleles compared with HP 1, rs1723540 A, and rs2276631 A alleles.

Conclusion. Within the limitations of this study, it seems that there was a relationship between HP and NRAMP1 allele frequencies and the presence of heme-consuming periodontal pathogens in the Iranian patients with chronic periodontitis and peri-implantitis evaluated in the present study.

Keywords: Chronic Periodontitis, Haptoglobin, Microorganism, NRAMP1, Pathogens, Peri-implantitis
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